LONG-TERM STUDY OF INHALED PLUTONIUM IN DOGS.
Technical rept., 1 Sep 59-30 Apr 65,
BATTELLE MEMORIAL INST RICHLAND WASH
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To determine the long-term translocation and biological effects of inhaled plutonium, 40 beagle dogs were given a single 10- to 30-min exposure to Pu23902 aerosols. Thirteen dogs died or were sacrificed when clinical signs indicated death was imminent 29 to 66 months postexposure. The body burdens at death ranged from 0.5 to 3 micro Ci with 40 to 75 per cent of the body burden in the lungs, and 20 to 50 per cent in the bronchial and mediastinal lymph nodes. The liver contained 2 to 21 per cent, and the skeleton, 1 to 7 per cent. Cardiopulmonary insufficiency and lymphopenia were the primary clinical signs. Pathology in the lungs consisted of severe fibrosis followed by alveolar cell hyperplasia, and bronchiolar and squamous types of metaplasia. Seven of the 13 animals showed bronchiolo-alveolar carcinomas, an incidence of 18 per cent as compared to a reported canine primary lung-tumor incidence of 0.2 per cent. The bronchial lymph nodes were composed of dense sclerotic connective tissue devoid of any lymphoid element. Metastases of the pulmonary tumor to the bronchial lymph nodes were seen in three animals. Twenty-three dogs with body burden of 0.3 to 1 micro Ci survived 4 to 6 yr after exposure. Author