Accession Number:

AD0631226

Title:

FURTHER OBSERVATIONS ON POTENTIAL IMMUNOLOGICALLY COMPETENT CELLS OF FETAL LIVER ORIGIN,

Descriptive Note:

Corporate Author:

NAVAL RADIOLOGICAL DEFENSE LAB SAN FRANCISCO CALIF

Personal Author(s):

Report Date:

1966-03-10

Pagination or Media Count:

24.0

Abstract:

Using a modified graft-versus-host method, attempts were made to promote the maturation of potential immunologically competent cells of fetal liver origin parental in thymectomized F1 hybrid hosts by means of irradiated and nonirradiated syngeneic with respect to the fetal liver cells and allogeneic thymus grafts, suspensions of cells from syngeneic thymus, and syngeneic and allogeneic thymus placed in diffusion chambers. It was found that, in this experimental model, only those thymus grafts which survived in the primary host for a prolonged period i.e., syngeneic and to which the fetal liver cells had direct physical access would promote the maturation of these lymphoid precursor cells. In addition it was noted that 1 the method used had immunologic specificity 2 viable fetal liver cells or thymus grafts were required in all experimental systems 3 18-20 day dissociated fetal thymus gave no evidence of the presence of either mature or immature lymphoid cells and 4 potential immunologically competent cells appeared to be incapable of producing hemagglutinins to rat erythrocytes or of rejecting allogeneic or xenogeneic skin grafts in the absence of the host thymus. Author

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE