Accession Number:

AD0630103

Title:

EFFECTS OF TOTAL-BODY X IRRADIATION ON PERITONEAL AND CIRCULATING LEUCOCYTES OF MICE,

Descriptive Note:

Corporate Author:

NAVAL RADIOLOGICAL DEFENSE LAB SAN FRANCISCO CALIF

Personal Author(s):

Report Date:

1966-01-13

Pagination or Media Count:

26.0

Abstract:

Total-body X irradiation over a wide range of doses was found to alter the number and distribution of cells in the peritoneal cavity of unstimulated LAF-1 mice. Unirradiated controls yielded 5-7 x 10 to the 6th power mononuclear cells, about 30 of which were macrophages and 70 small and medium lymphocytes. Following exposure to sublethal X ray doses 90-590 R, macrophage counts were essentially unaltered for two weeks but declined slightly during the 3rd week after 390-590 R. Following a midlethal dose 690 R, the number of macrophages was unchanged for one week but fell to about 50 of the normal value by 21 days postirradiation. After lethal irradiation 790-1190 R, macrophage counts remained unaltered for 3 days but decreased on the 7th day. The number of lymphocytes in the peritoneal cavity decreased sharply within 24 hours after every dose employed and then declined further at a more gradual rate. Both the initial and the subsequent disappearance of lymphocytes increased in severity with increasing exposure. During the first week postirradiation, a linear relation existed between the percentage of lymphocytes in the peritoneal cell population and the X ray dose. Author

Subject Categories:

  • Radiobiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE