RESEARCH ON INTRA NEURONAL MECHANISMS FOR INFORMATION STORAGE.
GOTEBORG UNIV (SWEDEN) DEPT OF HISTOLOGY
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Different types of micro-chemical methods used for analysis of neurons and glia are discussed. As an introduction to a discussion of a biochemical response in neuron and glia during learning, a few basic problems are mentioned and some pertinent results are given. The neurons are especially rich in RNA and during a life-cycle in man, there can be discerned a rise, steady level and fall in the RNA content of moto-neurons. What this cycle of changes means from a functional point of view, seems to be an important problem to consider for future studies. During sleep-wakefulness, rhythmic enzyme changes were recorded alternating between the neurons and glia in the caudal part of the reticular formation in rabbits. These changes are taken to reflect circadian, rhythmic processes underlying the biological clock phenomenon. During physiological stimulation of the nervous system in mammals, an increase of the RNA content, total proteins and enzyme activities have been found in the neurons, and a decrease in the surrounding glia. To elucidate this phenomenon, a kinetic study and other experiments were carried out. The results showed that the neuron and its glia are coupled as a unit from an energetic point of view. Some RNA data from a study of Parkinsons disease are given to show that one part of the unit can influence the other from a biochemical as well as from a functional point of view. Author
- Anatomy and Physiology