RESEARCH ON THERAPY OF PULMONARY EDEMA ASSOCIATED WITH OXIDIZERS
Final rept. 15 May 1964-30 Jun 1965
HINE LABS INC SAN FRANCISCO CA
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An evaluation was made of candidate therapeutic agents for the treatment of acute pulmonary edema resulting from nitrogen dioxide exposure. Treatments consisting of hyperbaric air and oxygen tracheal toilet ethyl, isopropyl, and octyl alcohol vapors hydralazine bethanechol physostigmine and isoproterenol aerosols produced no change in the mortality, survival time, or lungbody weight ratios of rats suffering from N02-induced acute pulmonary edema. Rutin in large doses caused a decrease in mortality and an increase in survival time of exposed rats. Intravenous infusion of isoproterenol caused a decrease in mortality in rabbits exposed to N02. The effectiveness of hyperbaric oxygen, hydrocortisone, rutin and bethanechol against moderate exposure to N02 was determined by solvent uptake measurements with rats. Oxygen administered 4 hours after exposure increased solvent uptake. There were no significant effects due to the other compounds.