The Effect of Injected Monomethylhydrazine on Primate Performance
AIR FORCE AEROSPACE MEDICAL RESEARCH LAB WRIGHT-PATTERSON AFB OH
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Nine macaque monkeys were injected on two occasions with either 2.5 or 5.0 mgkg of monomethylhydrazine MMH. Operant task performance was measured, and clinical symptoms were noted. No difference in performance resulted from the two dosage levels, but there was a greater incidence of clinical symptoms in those subjects exposed to 5.0 mgkg. In over half the cases a performance decrement preceded clinical symptoms, but in no instance did clinical symptoms precede a performance decrement. In 318 cases clinical symptoms did appear without a performance decrement, but in 418 cases a performance decrement occurred in the absence of clinical symptoms. When initial 2.5 or 5.0 mgkg injections are made one might predict that performance decrements will occur between 1 and 2 hours and clinical symptoms between 2 and 2.5 hours in about half the subjects. A second exposure might be expected to produce performance decrements between 1 and 2 hours and clinical symptoms between 2 and 3 hours in the majority of subjects. If a subject is influenced by MMH, clinical symptoms will likely disappear between 3 and 9 hours following injection, and performance should return to baseline level between 3 and 30 hours.