THE EFFECT OF CHLORPROMAZINE AND AMPHETAMINE ON CONCEPTUAL DIFFERENTIATION.
Technical rept., Mar-Apr 65,
CHEMICAL RESEARCH AND DEVELOPMENT LABS EDGEWOOD ARSENAL MD
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The purpose of the studies was to determine if chlorpromazine and amphetamine have opposite effects on conceptual differentiation the measure of an individuals mode of categorizing perceived similarities and differences. In the first experiment, 10 mg of amphetamine and 25 mg of chlorpromazine were administered orally to the subjects, each drug on a different day. During the expected peak reaction, the Object Sorting Test OST, the selected measure of conceptual differentiation, was administered to the subjects in a group. It was predicted that in the OST amphetamine would result in the use of many groupings, while chlorpromazine would result in the use of relatively few groupings. The difference in number of groups used under either drug was not significant. In the second experiment, different subjects were tested in essentially the same manner but with the following modifications 1 subjects were selected from the upper end of the General Technical Aptitude Area Test GT distribution, 2 the OST was administered individually with an inquiry period at the end, and 3 the dose of amphetamine was increased to 15 mg and chlorpromazine to 50 mg orally. These modifications resulted in less variability from subject to subject, but the difference in the number of groupings was, again, insignificant. The hypothesis that chlorpromazine would result in less groupings on the OST and amphetamine in more groupings was tested. Two tests were made of the hypothesis, and in both cases there were no significant differences between the number of groups sorted under the two drugs. Author