Accession Number:

AD0627996

Title:

BOTULINUM ANTITOXIN AS A THERAPEUTIC AGENT IN MONKEYS WITH EXPERIMENTAL BOTULISM

Descriptive Note:

Technical rept. Jan 1963-Aug 1964

Corporate Author:

CHEMICAL RESEARCH AND DEVELOPMENT LABS EDGEWOOD ARSENAL MD

Report Date:

1965-10-01

Pagination or Media Count:

15.0

Abstract:

Antitoxin administered soon after the appearance of the first toxic signs in monkeys given 2.5 to 5.0 LD50s of botulinum toxin resulted in complete recovery in 11 out of 15 animals when liquid food and fluids were forced during the period of aphagia. When no supportive treatment was applied, only one out of six survived. The survivor had received 2.5 LD50s of toxin. It is concluded that most monkeys given 2.5 to 5.0 LD50s of botulinum toxin intravenously can be saved when the antitoxin is administered soon after the first toxic signs are detected and when daily, supplemental, intragastric feedings, vitamins and antibiotics are given.

Subject Categories:

  • Medicine and Medical Research
  • Toxicology
  • Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE