Accession Number:

AD0627842

Title:

EFFECTS OF PAMC1 AND TMB-4 ON NEUROMUSCULAR TRANSMISSION. II. EFFECTS ON ISOLATED RAT PHRENIC-NERVE DIAPHRAGM-MUSCLE PREPARATION.

Descriptive Note:

Technical rept. Jan 61-Apr 62,

Corporate Author:

CHEMICAL RESEARCH AND DEVELOPMENT LABS EDGEWOOD ARSENAL MD

Report Date:

1965-07-01

Pagination or Media Count:

23.0

Abstract:

The effects of pyridine-2-aldoxime methochloride PAMC1 and 1,1-tri-methylene-bis 4-formyl-pyridinium bromide dioxime TMB 4 on neuromuscular transmission in the isolated rat-phrenic-nerve diaphragm preparation were studied in the absence of organophosphate anticholinesterases. Both PAMC1 and TMB-4 antagonized the initial neuromuscular block resulting from addition of depolarizing agents. After prolonged exposure to the latter, the addition of PAMC1 and TMB-4 increased the block in a manner similar to that of d-tubocurarine. Tetraethyl ammonium TEA antagonized the depression of response to indirect stimulation following addition of PAMC1. Author

Subject Categories:

  • Anatomy and Physiology
  • Pharmacology
  • Chemical, Biological and Radiological Warfare

Distribution Statement:

APPROVED FOR PUBLIC RELEASE