EFFECTS OF PAMC1 AND TMB-4 ON NEUROMUSCULAR TRANSMISSION. II. EFFECTS ON ISOLATED RAT PHRENIC-NERVE DIAPHRAGM-MUSCLE PREPARATION.
Technical rept. Jan 61-Apr 62,
CHEMICAL RESEARCH AND DEVELOPMENT LABS EDGEWOOD ARSENAL MD
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The effects of pyridine-2-aldoxime methochloride PAMC1 and 1,1-tri-methylene-bis 4-formyl-pyridinium bromide dioxime TMB 4 on neuromuscular transmission in the isolated rat-phrenic-nerve diaphragm preparation were studied in the absence of organophosphate anticholinesterases. Both PAMC1 and TMB-4 antagonized the initial neuromuscular block resulting from addition of depolarizing agents. After prolonged exposure to the latter, the addition of PAMC1 and TMB-4 increased the block in a manner similar to that of d-tubocurarine. Tetraethyl ammonium TEA antagonized the depression of response to indirect stimulation following addition of PAMC1. Author
- Anatomy and Physiology
- Chemical, Biological and Radiological Warfare