Accession Number:

AD0625941

Title:

BIOCHEMICAL AND GENETICAL STUDIES ON INH METABOLISM

Descriptive Note:

Semi-annual rept. 2 Jun-1 Dec 1964

Corporate Author:

TOKYO NATIONAL CHEST HOSPITAL (JAPAN)

Personal Author(s):

• Sunahara, Shigeichi

Report Date:

1964-12-01

Pagination or Media Count:

29.0

Abstract:

It was established that the inactivation of isoniazid in humans was a genetic trait and there was not only individual but also racial difference. The frequency distribution curve of the biologically active isoniazid serum levels 6 hours after the oral administration of 4 mgkg of body weight of isonizzid is trimodal, corresponding to the three phenotypes of isoniazid metabolism--rapid, intermediate and slow inactivators. On the other hand, it was observed in vitro that there was very remarkable species and drug differences in the acetylation of isoniazid, sulfonamide and PABA by the liver homogenate of various kinds of animals, and the most active site of acetylation was the liver. The purpose of the present research is to examine the correlation between the blood concentration and the capacity of tissue to acetylate isoniazid using Cynomoldus monkeys as animals of experiment.

Descriptors:

• *ISONIAZID
• TISSUES(BIOLOGY)
• METABOLISM
• IN VITRO ANALYSIS
• JAPAN
• LIVER
• GENETICS
• MONKEYS
• BLOOD CHEMISTRY

Subject Categories:

• Biochemistry
• Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE