Accession Number:

AD0623786

Title:

1, 1-DIMETHYLHYDRAZINE EFFECTS ON CENTRAL EXCITATORY AND INHIBITORY MECHANISMS IN CATS

Descriptive Note:

Final rept. Jan 1964-Jun 1965

Corporate Author:

CALIFORNIA UNIV LOS ANGELES BRAIN RESEARCH INST

Personal Author(s):

• Fairchild, M. D.
• Sterman, M. B.

Report Date:

1965-08-01

Pagination or Media Count:

41.0

Abstract:

Experiments, using cats with chronically implanted brain electrodes, were performed to explore the influence of subconvulsive doses of 1, 1- dimethylhydrazine UDMH on certain excitatory and inhibitory mechanisms in the central nervous system CNS. The cats were stimulated electrically in the midbrain reticular activating system, the basal forebrain inhibitory area, and both areas simultaneously while the animal was tested for performance in a positively reinforced experimental situation. UDMH was compared with amphetamine, chlorpromazine and phenobarbital both in the presence and absence of CNS stimulation. UDMH acted in a manner similar to chlorpromazine in subconvulsive doses in these tests. The most interesting and consistent effect of UDMH was to abort performance when the basal forebrain inhibitory area was stimulated. The animals resumed performance when the stimulus was terminated. UDMH has detectable CNS effects at doses well below convulsive levels.

Descriptors:

• *DIMETHYLHYDRAZINES
• BRAIN
• TOXICITY
• BEHAVIOR
• CNS DEPRESSANTS
• CONVULSIVE DISORDERS
• CNS STIMULANTS
• AMPHETAMINES
• BARBITURATES
• CHLORPROMAZINE

Subject Categories:

• Medicine and Medical Research
• Stress Physiology
• Toxicology
• Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE