Accession Number:

AD0623477

Title:

THE ROLE OF NACL IN THE LYSIS OF STAPHYLOCOCCUS AUREUS BY LYSOSTAPHIN,

Descriptive Note:

Corporate Author:

ARMED FORCES INST OF PATHOLOGY WASHINGTON D C

Personal Author(s):

• Schindler,C. A.

Report Date:

1965-04-07

Pagination or Media Count:

8.0

Abstract:

Lysostaphin attacked both viable staphylococci and the mucopeptide portion of the staphylococcal cell wall. In the absence of salts, lysostaphin activity could only be recovered from the particulate portion of the lysed cell after centrifugation, whereas in the absence of salts its action on the mucopeptide resulted in a recovery of active material in both the sediment and the supernatant fluid. It appears from these observations that lysostaphin is complexed with its substrate and that NaCl is required to break the complex. Author

Descriptors:

• (*STAPHYLOCOCCUS AUREUS
• DEGRADATION)
• SODIUM COMPOUNDS
• CHLORIDES
• VIABILITY
• GLYCOPROTEINS
• CELL WALL
• SALTS
• CHEMICAL ANALYSIS
• AMINO ACIDS
• PREPARATION
• PURIFICATION

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE