Accession Number:

AD0623321

Title:

SCREENING OF NEW CHELATING AGENTS FOR BERYLLIUM

Descriptive Note:

Final rept. Jun 1964-Mar 1965

Corporate Author:

INTERNATIONAL BIO-RESEARCH INC ST LOUIS MO

Personal Author(s):

• Sterner, Wolfgang
• Loveless, L. E.

Report Date:

1965-08-01

Pagination or Media Count:

31.0

Abstract:

Thirteen polyaminopolycarboxylic acid chelating agents were evaluated in vitro and in vivo as potential therapeutic agents for acute beryllium poisoning. In the in vitro test system the ability of the chelating agent to reverse beryllium induced inhibition of alkaline phosphate was measured. In the in vivo system, the chelating agent was evaluated by its ability to prevent mortality of rats that had received an acute lethal dose of beryllium sulfate. None of the polyaminopolycarboxylic acids reversed completely the inhibition of alkaline phosphatase at either 35 percent or 65 percent levels of inhibition. All compounds were ineffective in overcoming the toxic dose of beryllium in rats.

Descriptors:

• *BERYLLIUM
• *CHEMICAL PRECIPITATION
• *CHELATING AGENTS
• RATS
• POLYMERS
• SELECTION
• SOLID PROPELLANTS
• PHOSPHORIC MONOESTER HYDROLASES
• METAL POISONING
• ETHYLENEDINITRILO TETRAACETATES
• CHEMOTHERAPEUTIC AGENTS
• LETHAL DOSAGE
• TOXICITY
• AMINES
• THERAPY

Subject Categories:

• Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE