STUDY OF FLUORESCENT EMISSION FROM THE CAT CEREBRAL CORTEX.
Final rept. for Jan-Aug 64,
BATTELLE MEMORIAL INST COLUMBUS OHIO
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Experiments were conducted to investigate the existence of changes in fluorescence properties of the cat cerebral cortex during cortical and peripheral electrical stimulation. In anesthetized cats, the exposed cortex was illuminated with the light output from a monochromator and fluorescence changes were detected by use of a photomultiplier tube. Appropriate filters were used to prevent response of the photomultiplier to light from the excitation source. When electrical pulse stimulus of electroconvulsive intensity was applied by means of a wick electrode to the brain surface, there were observed signals of several millivolts amplitude from the photomultiplier tube interpreted as fluorescence changes. An interpretation is tentatively proposed which is based upon changes in relative proportions of oxidized and reduced pyridine nucleotide in the cortical tissue. Author