A BIOASSAY OF THE PROMINENT HUMORAL AGENTS INVOLVED IN ENDITOXIN SHOCK.
Technical rept. for Nov 63-Jul 64,
CHEMICAL RESEARCH AND DEVELOPMENT LABS EDGEWOOD ARSENAL MD
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This report defines the release of neurohumoral substances into the circulation after the intravenous administration of a lethal dose of E. coli endotoxin. An isolated saphenous vein in circuit with either an intact or a surgically eviscerated dog allowed the measurement of vessel-tension changes and afforded a continuous bioassay of the existing neurohumoral balance blocking agents were used to define the agent that was active at any one given time. Histamine, or a similar compound, was active in the first phase of shock with catecholamines playing the predominant role during the second hypotensive phase. A parasympathetic-like response third phase, causing bradycardia and hypotension, was also noted. Author