Accession Number:
AD0621508
Title:
A BIOASSAY OF THE PROMINENT HUMORAL AGENTS INVOLVED IN ENDITOXIN SHOCK.
Descriptive Note:
Technical rept. for Nov 63-Jul 64,
Corporate Author:
CHEMICAL RESEARCH AND DEVELOPMENT LABS EDGEWOOD ARSENAL MD
Personal Author(s):
Report Date:
1965-03-01
Pagination or Media Count:
17.0
Abstract:
This report defines the release of neurohumoral substances into the circulation after the intravenous administration of a lethal dose of E. coli endotoxin. An isolated saphenous vein in circuit with either an intact or a surgically eviscerated dog allowed the measurement of vessel-tension changes and afforded a continuous bioassay of the existing neurohumoral balance blocking agents were used to define the agent that was active at any one given time. Histamine, or a similar compound, was active in the first phase of shock with catecholamines playing the predominant role during the second hypotensive phase. A parasympathetic-like response third phase, causing bradycardia and hypotension, was also noted. Author