Accession Number:

AD0621508

Title:

A BIOASSAY OF THE PROMINENT HUMORAL AGENTS INVOLVED IN ENDITOXIN SHOCK.

Descriptive Note:

Technical rept. for Nov 63-Jul 64,

Corporate Author:

CHEMICAL RESEARCH AND DEVELOPMENT LABS EDGEWOOD ARSENAL MD

Personal Author(s):

Report Date:

1965-03-01

Pagination or Media Count:

17.0

Abstract:

This report defines the release of neurohumoral substances into the circulation after the intravenous administration of a lethal dose of E. coli endotoxin. An isolated saphenous vein in circuit with either an intact or a surgically eviscerated dog allowed the measurement of vessel-tension changes and afforded a continuous bioassay of the existing neurohumoral balance blocking agents were used to define the agent that was active at any one given time. Histamine, or a similar compound, was active in the first phase of shock with catecholamines playing the predominant role during the second hypotensive phase. A parasympathetic-like response third phase, causing bradycardia and hypotension, was also noted. Author

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE