Accession Number:

AD0621458

Title:

MECHANISM OF HAEMOLYSIS BY COMPLEMENT,

Descriptive Note:

Corporate Author:

JOHNS HOPKINS UNIV BALTIMORE MD SCHOOL OF MEDICINE

Personal Author(s):

Report Date:

1965-01-01

Pagination or Media Count:

30.0

Abstract:

Recent studies of immune haemolysis have been concerned with isolation and characterization of intermediates, investigation of the successive steps, development of the one-hit theory, design of precise analytical methods for measurement of CI, C2 and C4, and elucidation of the enzymic action of CIa. What was formerly known as C3 has been resolved into five distinct factors but knowledge of the intermediate steps in this phase of the system is still sketchy. While the mechanism of cytocidal action is still unsolved, many new tools are now available for studying the nature of complement as well as its participation in immune defence, hypersensitivity reactions, autoimmune phenomena and graft rejection. Author

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE