Accession Number:

AD0621180

Title:

STUDIES ON HUMAN ANTIBODIES. III. AMINO ACID COMPOSITION OF FOUR ANTIBODIES FROM ONE INDIVIDUAL,

Descriptive Note:

Corporate Author:

COLUMBIA UNIV NEW YORK COLL OF PHYSICIANS AND SURGEONS

Report Date:

1965-04-05

Pagination or Media Count:

11.0

Abstract:

Antilevan, antidextran, antiteichoic acid, anti- A and normal gamma G, all isolated from a single human, as well as pooled gamma G and gamma M, were analyzed for amino acid content. Differences ranging from 7 to 32 residues were found among these antibodies in glycine, valine, leucine, tyrosine, arginine, lysine, and threonine content. These conspicuous differences in amino acid composition were not correlated with the Gm type of these antibodies. Hydroxylysine was found in two of the four antibodies, antidextran and antiteichoic acid, and in gamma M- immunoglobulin. No hydroxylysine was found in gamma G- globulins. These findings probably account for discrepancies in the literature concerning the occurrence of this residue in antibody protein. Author

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Distribution Statement:

APPROVED FOR PUBLIC RELEASE