Accession Number:

AD0620967

Title:

THE EFFECTS OF X-IRRADIATION ON GASTRIC MOTILITY IN THE DOG,

Descriptive Note:

Corporate Author:

FOREIGN TECHNOLOGY DIV WRIGHT-PATTERSON AFB OHIO

Personal Author(s):

Report Date:

1965-06-25

Pagination or Media Count:

15.0

Abstract:

Sublethal doses of x-irradiation did not have a pronounced effect on the motility of the empty stomach in dogs. The characteristic changes were increased strength of contraction and rapid recovery. A lethal dose of radiation caused a marked change in gastric motility. Immediately after the irradiation, gastric motility disappeared. Although the motility resumed subsequently, a sustained normal state was seldom reached. If the depression occurred, in most cases chances for full recovery were nil. In a few animals, after the first depression, the gastric motility fluctuated for several months before returning to normal. If, however, a second depression occurred after an extended normalization period, death usually followed. The extent of the gastric motility alteration may be used as an index to the severity of the radiation syndrome, as a basis for understanding of the nature of the gastrointestinal disturbance in radiation sickness, and eventually for its treatment. Since gastric motility is under the regulation of the CNS, its changes may also reflect the state of the CNS. Author

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE