THE GIANT-CELL OF REPARATIVE GRANULOMAS: A REVIEW OF THE LITERATURE AND ANALYSIS OF 146 CASES.
INDIANA UNIV INDIANAPOLIS SCHOOL OF DENTISTRY
Pagination or Media Count:
An attempt was made to understand the nature of the giant-cell reparative granuloma and its natural history from a study of 146 biopsy specimens and case histories. A survey of the clinical features, the histopathology and histochemical enzyme determinations on selected cases suggests that the lesion is in the nature of a hyperplastic tissue response, primarily fibrogenic or fibrovascular in character and arising primarily from the periodontal ligament and periosteum of the jaws. The lesional giant cells were indistinguishable both morphologically and histochemically from osteoclasts and, save for their relationship to bone, are considered to be essentially the same cell type. Study of the site, age, and sex incidence suggests that the shedding of the deciduous dentition may be a common etiological factor common to both sexes and an attempt has been made to relate this, at least in some instances, to the absorbent organ of Tomes. Predominance of lesions in females throughout the child-bearing age suggests that an endocrine effect on tissue response may be an important etiologic factor. Author