THE RELATIONSHIPS IN VIVO BETWEEN CARBON MONOXIDE, OXYGEN AND HEMOGLOBIN IN THE BLOOD OF MAN AT ALTITUDE
NAVAL SCHOOL OF AVIATION MEDICINE PENSACOLA FL
Pagination or Media Count:
Three male subjects were studied at varying pressurealtitudes while in equilibrium with inspired gas mixtures containing from 0.005 to 0.015 per cent carbon monoxide. The distribution of COHb, O2Hb and reduced Hb and their related gas tensions confirm in vivo the fundamental laws first defined by Haldane for the equilibria obtaining in vitro. A simple rearrangement of the Haldane equation makes possible an accurate prediction of the amount of COHb obtaining when man is in equilibrium with a CO-contaminated atmosphere at any given altitude. The value of the relative affinity constant of Hb for CO compared to O2 was found to be 204 10 p.c. in these experiments. The total barometric pressure has been found to play no role in the distribution of CO and O2 at equilibrium. The hemoglobin of individuals who smoke appears not to differ from that of non-smokers in its affinity for CO and O2. The symptoms produced by CO are proportional not only to the blood concentration of COHb but also to the duration of exposure to a given concentration.
- Anatomy and Physiology