Accession Number:

AD0619919

Title:

HEPATIC IRON STORAGE AND ERYTHROKINETICS AFTER PORTACAVAL SHUNT,

Descriptive Note:

Corporate Author:

WALTER REED ARMY INST OF RESEARCH WASHINGTON D C

Report Date:

1964-03-24

Pagination or Media Count:

10.0

Abstract:

The concentration of hepatic storage iron nonheme iron is increased by 62.3 percent after portacaval shunting in dogs. Such increase is presumably due to the presence of an increased amount of hemosiderin, as observed on microscopic examination of sections of liver. Because of the known reduction of liver volume and the suspected reduction of hepatic ferritin concentration after shunting, the increase in the concentration of hepatic storage iron is a reflection of the increase in hepatic hemosiderin concentration. Hepatic storage iron concentration is not an accurate index of either the increase in hepatic storage iron content or hepatic hemosiderin content. The serum iron concentration declines rapidly from 154 micrograms to 60 micrograms per 100 ml. after portacaval shunt and returns slowly to the level prior to operation, while the serum iron-binding capacity rises slowly from 186 to 238 micrograms per 100 ml. after portacaval shunt. The osmotic fragility and half-life of the red cells Cr51 do not change significantly after portacaval shunt. These results suggest that hematopoiesis is generally depressed as a result of the portacaval shunt, and that iron previously used in the production of hemoglobin is stored in the liver as hemosiderin. The significance of these findings relative to the reported human cases of hemochromatosis after portal-systemic shunting is discussed. Author

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE