Accession Number:

AD0619901

Title:

STUDIES OF HEMOSTASIS IN THAI HEMORRHAGIC FEVER,

Descriptive Note:

Corporate Author:

SEATO MEDICAL RESEARCH LAB BANGKOK (THAILAND)

Personal Author(s):

Report Date:

1965-01-01

Pagination or Media Count:

10.0

Abstract:

Studies of hemostasis were performed on 27 children with Thai hemorrhagic fever from dengue virus during September, 1962. The most common finding was moderate to severe thrombocytopenia. The platelet count was usually decreased when the patients were first seen, and became maximally depressed 5 to 9 days after the onset of clinical symptoms. Thereafter, the count returned rapidly to normal. Bone marrow megakaryocytes were normal to increased in number and were often young and fragmented. In 5 patients there was a moderate prolongation of the one-stage prothrombin time, due to decreases in factor II prothrombin, factor V labile factor, and factors VII X. These abnormalities were found in patients with the most sever liver disease. A marked prolongation of the silicone clotting time was observed in 11 patients and was out of proportion to the thrombocytopenia or the moderate depression of factors V and X. Author

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE