Accession Number:

AD0619885

Title:

THE VACCINAL PROCESS IN GUINEA PIGS SIMULTANEOUSLY IMMUNIZED WITH BRUCELLA AND Q-FEVER LIVE VACCINES,

Descriptive Note:

Corporate Author:

ARMY BIOLOGICAL LABS FREDERICK MD

Personal Author(s):

Report Date:

1965-07-01

Pagination or Media Count:

11.0

Abstract:

The simultaneous administration of brucellosis and Q-fever live vaccines by both the subcutaneous and cutaneous methods did not exert an unfavorable influence on the organism of guinea pigs. The local and general reaction of the organism to the simultaneous administration of these two vaccines was expressed to the same degree as with the influence of monovaccines. In guinea pigs the subcutaneous and cutaneous vaccination with two live vaccines caused an immunological reorganization in respect to both antigens, which was caused by the seeding of the organism with brucella and rickettsiae. The dynamics of the immunological processes, their duration and the degree of expression in respect to each antigen hardly differed from the corresponding indices in the control animals. The results obtained make it possible to assume the feasibility of the simultaneous immunization of humans with brucellosis and Q-fever live vaccines. Author

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE