COMPARISON OF SEQUENTIAL EXPERIMENTS FOR ESTIMATING THE MEDIAN LETHAL DOSE.
HARVARD UNIV CAMBRIDGE MASS
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Some designs for biological assays with quantal responses are reviewed. Five sequential experimental designs are compared with two non-sequential designs. The method of computation and the conditions under which the conceptual experiments are conducted are given. The distribution of the median lethal dose estimate is summarized by its variance, squared bias, mean square error about m and measures of skewness and kurtosis. The mean square errors are graphed, tabled, and discussed for sequential and non-sequential experiments.