SOME GENERAL REGULARITIES IN THE FORMATION OF L-FORMS IN VARIOUS PATHOGENIC SPECIES OF BACTERIA
ARMY BIOLOGICAL LABS FREDERICK MD
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Many pathogenic species of bacteria are capable of L-transformation. This capacity was more pronounced in the Gram-negative bacteria and less--in the Grampositive ones. L-form production depended on the culturing conditions, the character of actions used and their intensity. With equal conditions there were strains within the range of the given species, possessing different capacity to L-transformation with a subsequent stabilization in L-form. L-form populations are heterogenic by their capacity to L-transformation. Along with the cells, which are relatively easily transformed into L-form under the effect of transforming agents, there occur cells with a limited capacity to L-transformation and nonviable ones, rapidly perishing in the given conditions. Stable L-forms are produced as a result of the primary reaction to the transforming action, or as a result of prolonged passage of various heteromorphic growth forms and of nonstable L-forms in conditions of the transforming agent action. Nonstable L-forms may be regarded as modifications. The mechanisms of the stable L-form production are still obscure nevertheless there is basis for supposition concerning the mutation-selective process of L- transformation, in which the transforming agents induce the appearance of L-forms and simultaneously lead to the selection of the appearing L-mutants.