SERUM PROTEINS OF GERM-FREE RATS FED WATER-SOLUBLE DIETS,
NOTRE DAME UNIV IND LOBUND INST
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The report presents data on serum proteins of germfree rats fed a chemically defined, water-soluble antigen free diet which was filter-sterilized. This type of diet, composed almost entirely of low-molecularweight compounds and free of material of bacterial origin, should further reduce the level of reticuloendothelial system activity because of the absence of stimulation caused by high-molecular-weight substances and by killed and disintegrated microbial agents. The results indicate that, although most of the reticuloendothelial system stimulating material presumably occurring in the heat-sterilized solid-type diet is obviously absent in the filter-sterilized water-soluble formula, little if any further reduction in gamma-globulin levels is seen in germ-free rats fed this diet. Data obtained from germfree guinea-pigs have demonstrated the strong reticuloendothelial system stimulating effect of certain solid diets. It is possible that this effect of solid diets is much less noticeable in the germ-free rat.