Accession Number:

AD0618859

Title:

SERUM PROTEINS OF GERM-FREE RATS FED WATER-SOLUBLE DIETS,

Descriptive Note:

Corporate Author:

NOTRE DAME UNIV IND LOBUND INST

Report Date:

1964-01-01

Pagination or Media Count:

4.0

Abstract:

The report presents data on serum proteins of germfree rats fed a chemically defined, water-soluble antigen free diet which was filter-sterilized. This type of diet, composed almost entirely of low-molecularweight compounds and free of material of bacterial origin, should further reduce the level of reticuloendothelial system activity because of the absence of stimulation caused by high-molecular-weight substances and by killed and disintegrated microbial agents. The results indicate that, although most of the reticuloendothelial system stimulating material presumably occurring in the heat-sterilized solid-type diet is obviously absent in the filter-sterilized water-soluble formula, little if any further reduction in gamma-globulin levels is seen in germ-free rats fed this diet. Data obtained from germfree guinea-pigs have demonstrated the strong reticuloendothelial system stimulating effect of certain solid diets. It is possible that this effect of solid diets is much less noticeable in the germ-free rat.

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE