PHYSIOLOGICAL AND ENVIRONMENTAL INFLUENCES ON THE METABOLISM OF THYROID HORMONES.
Annual progress rept. for 1 Jul 64-30 Jun 65,
WASHINGTON UNIV SEATTLE
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The object of the research was 1 to determine the effects of disease, physiological alternations and environmental conditions on the peripheral metabolism of thyroid hormones and 2 to determine the effects of thyroid hormones on the intermediate metabolism of energyproviding substrates and on other neural and endocrine homeostatic mechanisms which are activated in certain disease states and during manipulations of the environment. Background During the past year the following topics were completed or extended 1 a second part of the studies of comparative physiology of thyroid hormone metabolism alternations in thyroxine metabolism during metamorphosis and molting in amphibia 2 additional studies of the hepatic incorporation of thyroxine in Graves disease, nodular toxic goiter, myxedema and in hepatic disease 3 the effects of thyrotoxicity on the renal concentrating mechanism in man and in rats and 4 further studies of anterior pituitary metabolism. Other work has been directed toward developing techniques for study of insulin antagonism, toward indirectly assessing the potency and duration of action of anabolic congeners of testosterone, and studies of iodine metabolism during human pregnancy.