Accession Number:

AD0618172

Title:

THE INFLUENCE OF EXTRACORPOREAL HANDLING OF BLOOD ON HEMORRHAGIC SHOCK IN DOGS,

Descriptive Note:

Corporate Author:

WALTER REED ARMY INST OF RESEARCH WASHINGTON D C

Report Date:

1965-01-01

Pagination or Media Count:

11.0

Abstract:

Summary and conclusions 1 Activation of surface clotting factors during extracorporeal handling of blood will greatly increase the mortality in hemorrhagic shock in dogs. 2 With careful handling of the blood exposing it only to plastic surfaces and avoiding metal, glass and air, dogs may be maintained for long periods at low pressures without the onset of irreversible shock. 3 Saline is nontoxic and quite helpful in hemorrhagic shock, whereas surface activated blood is toxic. Saline replacement is better than surface activated blood in treatment of hemorrhagic shock in dogs. 4 Heparin will prevent death in irreversible hemorrhagic shock and ameliorate the toxic effect of surface activated blood in dogs. 5 Mortality in dogs is correlated with fibrinogen utilization and a prolonged silicone clotting time. 6 Animals in hemorrhagic hypotension are predisposed to intravascular coagulation as compared with normal animals. 7 Irreversibility is correlated with the occurrence of an episode of disseminated intravascular coagulation DIC. Author

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Distribution Statement:

APPROVED FOR PUBLIC RELEASE