Accession Number:

AD0617981

Title:

EVIDENCE FOR A ROLE OF DOPAMINE IN EXTRAPYRAMIDAL FUNCTIONS,

Descriptive Note:

Corporate Author:

GOTEBORG UNIV (SWEDEN)

Personal Author(s):

Report Date:

1964-01-01

Pagination or Media Count:

11.0

Abstract:

Dopamine 3-hydroxytyramine is the immediate precursor in the biosynthesis of noradrenaline. In brain it probably also serves as a neurotransmitter, particularly in the extrapyramidal system. About 80 of the brain dopamine occur in the neostriatum. The intraneuronal localization of dopamine was demonstrated by means of histochemical techniques. Reserpine causes dopamine to disappear from the brain and produces a parkinsonian syndrome. The central actions of reserpine can be partially counteracted by increasing the concentration of dopamine in brain through administration of the precursor L-3,4-dihydrophenylalanineL-DOPA. In brains of parkinson patients the concentration of dopamine has been found markedly lowered the parkinson syndrome is favourably influenced by increasing the dopamine concentration through L-DOPA administration. Author

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE