Accession Number:

AD0617979

Title:

PROPOSED MODE OF ACTION OF CORTICOSTEROIDS ON THE CONNECTIVE TISSUE,

Descriptive Note:

Corporate Author:

CHILDREN'S HOSPITAL WASHINGTON D C BIOCHEMICAL RESEARCH LAB

Personal Author(s):

Report Date:

1965-01-01

Pagination or Media Count:

8.0

Abstract:

Previously reported changes in dermal chemistry associated with cortisol administration are explained on the basis of 1 a hormonally potentiated release of a cellular protease into the extracellular compartment of the connective tissue 2 the limited proteolytic activation of collagenase zymogen by this protease and 3 the digestion of insoluble collagen by the activated dermal collagenase. The dermal chemical responses of rats to cortisol were inhibited by Dilantin and by age, as was the ability of the steroid to effect the release of cellular protease into the ground substance.

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE