Accession Number:

AD0617366

Title:

ACUTE TOXICITY IN RATS AND RABBITS,

Descriptive Note:

Corporate Author:

AMERICAN OIL CO WHITING IND

Personal Author(s):

Report Date:

1965-06-25

Pagination or Media Count:

16.0

Abstract:

Compound LF-4713 was administered orally to albino rats at dosage levels extending from 250 to 10,000 mg.kg. Pharmacodynamic andor toxic signs were essentially absent at dosage levels through 5000 mg.kg. At 10,000 mg.kg. hypoactivity, ataxia, nasal and oral porphyrin discharge and flaccidity were observed over a 48-hour period. Three-of-five rats died within 48 hours at this dosage level. The acute oral LD50 value was 9260 6360-13,500 mg.kg. In primary skin and dermal LD50 studies in rabbits, LF-4713 was found to be devoid of irritating properties. No pharmacotoxic signs or mortalities were observed in either experiment. Instillation of LF-4713 into the eye of albino rabbits produced a mild conjunctivitis of 48-hour duration. The results of this test indicate that LF-4713 is not an irritant to the eye mucosa of the rabbit. Author

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE