ACUTE HEPATOTOXICITY AND ENZYMATIC RESPONSE TO HYDRAZINE AND 1,1-DIMETHYLHYDRAZINE IN RATS
Final rept. for Sep 1963-May 1964
OHIO STATE UNIV COLUMBUS
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The in vivo and in vitro effects of hydrazine and of 1, 1-dimethylhydrazine UDMH on blood serum and liver tissue enzyme activities were studied. The specific enzymes investigated were lactic dehydrogenase, isocitric dehydrogenase, malic dehydrogenase, and glumatic acid dehydrogenase. Activity levels were determined at 16, 24, 48, and 72 hours after intraperitoneal administration of the toxic agents to rats. Attempts were made to correlate enzyme levels with altered liver pathology. Results were compared with a concomitant study of the effects of carbon tetrachloride on the same enzymes and on liver pathology. Results indicated that the mechanisms of toxic action for these three chemical agents are probably dissimilar and that serum enzyme levels may not provide sensitive indications of altered liver pathology in the case of hydrazine or UDMH.