SMOOTH MUSCLE RESPONSES AS ALTERED BY HUMORAL BACKGROUND.
Final scientific rept.,
EDINBURGH UNIV (SCOTLAND)
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In man, monkey, rat and dog oxytocin normally has a vasodilator effect. Following surgical or chemical sympathetic denervation oxytocin becomes a vasoconstrictor. The dilator effect can be restored by infusing adrenaline or stimulating the sympathetic nerves. Oxytocin also becomes a vasoconstrictor when the circulating concentration of oestrogens is raised either naturally in the presence of oestrogens as in rats in oestrus or experimentally. In dogs the dilator response to oxytocin can be restored by giving atropine, and then either infusing adrenaline or stimulating the sympathetic nervous system. Author