Accession Number:

AD0614266

Title:

USE OF ISOPROTERENOL AND PHENOXYBENZAMINE IN TREATMENT OF ENDOTOXIN SHOCK,

Descriptive Note:

Corporate Author:

CHEMICAL RESEARCH AND DEVELOPMENT LABS EDGEWOOD ARSENAL MD

Report Date:

1965-04-01

Pagination or Media Count:

22.0

Abstract:

This report evaluates five approaches to the treatment of endotoxin shock in the dog. The effect of endotoxin on physiological parameters and survival was noted. Dogs treated with hydrocortisone, isoproterenol, or a combination of the two, showed temporary improvement however, no significant increase in survival population was observed. Isoproterenol produced a remarkable increase in right ventricular pressure even as systemic blood pressure decreased. In contrast, hydrocortisone caused a sharp fall in both right ventricular and systemic blood pressures. Treatment with phenoxybenzamine corrected systemic acidosis, increased right ventricular output, and resulted in a 70 survival, even while arterial blood pressure was maintained at hypotensive levels. The administration of phenoxybenzamine in combination with isoproterenol produced the most remarkable results the cardiostimulatory effect of isoproterenol compensated for the vasodilation and apparent hypotension produced by phenoxybenzamine. Flow was maintained to vital tissues, and systemic blood pressure was held at clinically acceptable levels. This combined therapy presents a possible solution to treating a seriously hypotensive condition with an agent that further reduces blood pressure. Author

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE