SPECIFICITY OF GUINEA-PIG ANTIBODIES AND DELAYED HYPERSENSITIVITY,
ARMED FORCES INST OF PATHOLOGY WASHINGTON D C
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The immunological specificity of the delayed hypersensitivity response in guinea-pigs stands in direct contrast to the specificity of rabbit antibodies. As many authors have shown, the elicitation of the delayed hypersensitivity reaction appears to involve an obligatory participation of the carrier protein as well as the haptenic moiety. Based on this specificity difference, it has been suggested that the delayed response recognizes and requires an appreciably larger antigenic determinant than does conventional circulating antibody. These specificity differences have also been cited in support of the suggestion that delayed hypersensitivity is unrelated to other forms of immunological response. Since the results cited above were based on experiments involving two different animal species, it was of interest to examine the guinea-pig antibodies, frequently detectable in the circulation a few days after the development of delayed hypersensitivity to a single injection of a hapten-protein conjugate. The specificity of these antibodies was compared with that of the delayed reaction on one hand and of rabbit anti-hapten antibodies on the other.