Accession Number:

AD0613793

Title:

PRODUCTION OF DIABETES INSIPIDUS IN HYPOPHYSECTOMIZED RATS BY HYPOTHALAMIC LESIONS,

Descriptive Note:

Corporate Author:

PENNSYLVANIA UNIV PHILADELPHIA SCHOOL OF MEDICINE

Personal Author(s):

Report Date:

1961-05-17

Pagination or Media Count:

4.0

Abstract:

Lesions in the median eminence produced permanent diabetes insipidus DI in chronically hypophysectomized rats. Water turnover in these animals, however, was only about half of that observed when lesions were made in rats with intact pituitaries and was further characterized by absence of the normal interphase. Conversely, when hypophysectomy was performed in rats with DI, an immediate and sustained 50 reduction in water intake occurred. Administration of adrenocorticotropin to hypophysectomized rats with lesions caused significant augmentation of DI, but not to levels found in rats with DI and intact pituitaries. Neither somatotrophic hormone STH nor triiodothyronine increased water turnover when given to hypophysectomized animals with DI. Lesions in the median eminence of hypophysectomized rats induced an immediate increase in urine volume in the absence of water intake, which indicates that primary polyuria was responsible at least in part for the development of DI in hypophysectomized rats with lesions. Author

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE