ANALYSIS AND PHYSICOCHEMICAL STUDIES OF INTRAVENOUS FAT EMULSIONS AND COMPONENTS.
Rept. for 1 May 64-1 Mar 65,
APPLIED SCIENCE LABS INC STATE COLLEGE PA
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The report gives further data on chemical composition, particle size and pH variation in intravenous fat emulsions in current and recent use. Some retests were made on old emulsions of the previous reports. All of the new emulsions that have been received were tested. New colorimetric procedures with ferrous thiocyanate reagent show the presence of peroxy and hydroperoxy derivatives in varying amounts in most of the emulsions, apparently associated with triglycerides and phospholipids. Other colorimetric tests have been introduced, to detect carbohydrates and amine-type compounds. Improved thin layer chromatography development procedures indicate the presence of bound lipids in the water phase. A twodimensional TLC technique is illustrated. Practically all emulsions are continuing to show a decrease in pH as time passes. Some of the most recently submitted emulsions are showing a more rapid pH drop than has been previously noted. Author