Accession Number:

AD0613108

Title:

ACUTE TOXICITY STUDIES ON ETHANOL, PROPANOL, AND BUTANOL,

Descriptive Note:

Corporate Author:

TORONTO UNIV (ONTARIO)

Report Date:

1964-04-27

Pagination or Media Count:

8.0

Abstract:

Three series of 10 dogs each were used to study the effects of intravenously administered ethanol, propanol-1, and butanol-1. In normothermic dogs, with supported respiration and nitrous oxide anaesthesia after induction, the mean lethal doses for ethanol, propanol-1, and butanol-1 were 4.90, 2.42, and 1.26 gkg respectively. At a constant infusion rate, the blood alcohol levels increased almost linearly with time. Relationships between ethanol, propanol-1, and butanol-1 blood levels and blood pressure, pulse, and electrocardiogram were established. Two minutes cardiac standstill occurred at the following blood levels ethanol, 1499 mg100 ml propanol-1, 713 mg100 ml butanol-1, 279 mg100 ml. Author

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE