Accession Number:

AD0611972

Title:

EFFECT OF EGG YOLK AND PHOSPHATIDES ON ANTHRAX INFECTION OF RATS AND GUINEA PIGS

Descriptive Note:

Corporate Author:

ARMY MEDICAL UNIT FREDERICK MD

Report Date:

1964-09-02

Pagination or Media Count:

4.0

Abstract:

Suspension of anthrax spores or vegetative cells in phosphatidyl ethanolamine, or the related phosphatides, phosphatidyl serine and phosphatidyl inositol, markedly reduced the intraperitoneal median lethal dose for guinea pigs and Sprague-Dawley rats, thus duplicating the effect of whole chicken egg yolk. Quantitative considerations indicated that the amount of phosphatidyl ethanolamine present in yolk could account for the effect of yolk. Lecithin, the other major phosphatide of yolk, was ineffective. Phosphatidyl ethanolamine appeared to influence the initial phases of host-bacterium interaction.

Subject Categories:

  • Medicine and Medical Research

Distribution Statement:

APPROVED FOR PUBLIC RELEASE