FLUID BALANCE AND ELECTROLYTE DISTRIBUTION IN THE HUMAN BODY
RAND CORP SANTA MONICA CA
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A conceptual model and a mathematical method are presented for computing the physiological fluid and electrolyte distribution for selected body compartments of an average, young, 70-kilogram human male. The mathematical procedure simulates the physiological subsystems by incorporating all the known chemical reactions and electrochemical relations which seem necessary to establish the fluid and electrolyte distribution. Because the whole body is being considered, the relatively large number of computations required argues that a computer be employed. The construction of the model and the mathematical background is given in heuristic form only, with reference to earlier papers for rigorous development. Considerable detail is shown regarding the analysis of the computed results for a standard, steady-state, average, young, resting, 70-kg human male. The results of validation experiments, consisting of chemical stresses applied to the model, are discussed.
- Anatomy and Physiology