Accession Number:

AD0611761

Title:

STUDY OF THE PHYSIOLOGICAL CHEMICAL MECHANISMS OF THE TOXIC ACTION OF HYDRAZINES.

Descriptive Note:

Quarterly rept. no. 2, 1 Oct-31 Dec 62,

Corporate Author:

CORNELL UNIV ITHACA N Y

Personal Author(s):

Report Date:

1962-12-31

Pagination or Media Count:

11.0

Abstract:

The first four months of work have established procedures and also for the rat 1 provided symptomological evidence that hydrazine has a different mode of action from unsymmetrical dimethylhydrazine UDMH or monomethylhydrazine, 2 established LD50s with and without pyridoxine, 3 shown that UDMH and hydrazine stimulate respiration and inhibit glycolysis when brain slices from normal and poisoned rats are compared, 4 shown a profound e.g. 95 reduction in brain lactate by UDMH and hydrazine.

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE