STUDY OF THE PHYSIOLOGICAL CHEMICAL MECHANISMS OF THE TOXIC ACTION OF HYDRAZINES.
Quarterly rept. no. 2, 1 Oct-31 Dec 62,
CORNELL UNIV ITHACA N Y
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The first four months of work have established procedures and also for the rat 1 provided symptomological evidence that hydrazine has a different mode of action from unsymmetrical dimethylhydrazine UDMH or monomethylhydrazine, 2 established LD50s with and without pyridoxine, 3 shown that UDMH and hydrazine stimulate respiration and inhibit glycolysis when brain slices from normal and poisoned rats are compared, 4 shown a profound e.g. 95 reduction in brain lactate by UDMH and hydrazine.