Accession Number:

AD0611509

Title:

EFFECT OF ISONICOTINYL HYDRAZIDE ON THE PATH OF CARBON IN PHOTOSYNTHESIS,

Descriptive Note:

Corporate Author:

QUEEN MARY COLL LONDON (ENGLAND)

Report Date:

1959-01-01

Pagination or Media Count:

3.0

Abstract:

In a study of the pathways of incorporation of carbon-14 from labelled carbon dioxide into the amino-acids glycine and serine during photosynthesis, the compound isonicotinyl hydrazide isoniazid was used. Isoniazid had only a small effect on the total fixation of carbon-14 and on the distribution between the ethanol-soluble and ethanolinsoluble fractions. The incorporation of carbon-14 into sugar phosphates, phosphoglyceric acid, phosphoenol pyruvic acid, aspartic acid, malic acid, fumaric acid and alanine is considerably reduced by treatment with isoniazid. Incorporation into sucrose is stimulated at the lower concentration and slightly inhibited at the higher concentration. Incorporation into glycollic acid and glycine, is stimulated about 5- to 8-fold by treatment with 0.01 M isoniazid. Incorporation into serine is inhibited to the same extent as that into sugar phosphates, phosphoglyceric acid, etc. The results do not indicate specific inhibition of transaminases by isoniazid but suggest a different site of action. Extracted

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Distribution Statement:

APPROVED FOR PUBLIC RELEASE