Accession Number:

AD0611502

Title:

SOME BIOCHEMICAL EFFECTS OF BETA-MERCAPTOETHANOL ON THE LIVER OF MICE AND RATS (QUELQUES EFFETS BIOCHIMIQUES DU BETA-MERCAPTOETHANOL SUR LE FOIE DE SOURIS ET DE RAT),

Descriptive Note:

Corporate Author:

BRUSSELS UNIV (BELGIUM)

Personal Author(s):

Report Date:

1961-01-20

Pagination or Media Count:

10.0

Abstract:

The effects of beta-mercaptoethanol HSCH2-CH2OH on the biochemistry of mouse and rat liver were studied both in vivo and in vitro. The intra-peritoneal injection of mercaptoethanol has no appreciable effect on the soluble -SH, ATP, DNA, and RNA content of the cells. Mercaptoethanol exerts a very definite inhibitory effect on the incorporation of labeled amino acids into liver proteins both in vivo and in vitro 30-40 inhibition. Mercaptoethanol, if injected in vivo, does not set free one of the enzymes characteristic of lysosomes, acid phosphatase there is no liberation of acid phosphatase when a particulate fraction containing the lysosomes is treated by mercaptoethanol in vitro. Author

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE