Accession Number:

AD0611296

Title:

EFFECT OF RESERPINE ON THE RELEASE OF CATECHOLAMINES FROM ISOLATED NERVE AND CHROMAFFIN CELL GRANULES,

Descriptive Note:

Corporate Author:

KAROLINSKA INSTITUTET STOCKHOLM (SWEDEN)

Personal Author(s):

Report Date:

1961-01-27

Pagination or Media Count:

9.0

Abstract:

In a suspension of bovine splenic nerve granules, reserpine in concentrations of 10 to the minus 8th power to 10 to the minus 5th power M strongly inhibits the spontaneous release of noradrenaline. The catecholamine releasing action of tyramine on nerve granules is unaffected by low concentrations of reserpine, but is almost completely blocked by concentrations of 10 to the minus 5th power M. Reserpine is less active as inhibitor on suprarenal medullary granules from the rabbit and still less on cats medullary granules. The spontaneous release occurs at a lower rate in rabbits medullary granules than in those from the cat. No difference in the rate of release was found between adrenaline and noradrenaline from the cats medullary granules. After administration of dopa 100 mgkg i.v. in the rabbit the rate of release from the medullary granules was greatly enhanced. The possible action of reserpine as enzyme inhibitor is briefly discussed. Author

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE