Accession Number:

AD0611247

Title:

BIOLOGICAL EFFECTS OF NUCLEAR RADIATION ON THE MONKEY (MACACA MULATTA): TWO-YEAR EVALUATION

Descriptive Note:

Corporate Author:

SCHOOL OF AEROSPACE MEDICINE BROOKS AFB TX

Report Date:

1959-06-01

Pagination or Media Count:

49.0

Abstract:

Macaca mulatta monkeys were exposed to prompt neutron and gamma radiation from two nuclear detonations. At a period roughly two years postirradiation, the survivors were examined with respect to long-term effects on clinical appearance, peripheral hematology, behavior, and cataractogenesis. Recovery of erythroid indices in shot Wilson survivors was 1 functionally complete by about 9 weeks postexposure, 2 effected by production of larger hyperchromic erythrocytes with a normal hemoglobin concentration, and 3 followed by a possible macrocytic hyperchromic anemia for the majority of the 63- to 540day postexposure period. Lymphocytes of the myeloid series were the last to evidence recovery the single animal that died exhibited a unique lymphocytic hypoplasia, which suggests a differential effect on the precursor tissue. The results with respect to behavior parameters include 1 differences on preliminary Wisconsin General Test Apparatus training which support the hypothesis of a radiation-induced elevation of response threshold values, 2 learning-performance differences in the male radiation dosage groups which are in accord with previous researches on other groups of monkeys, 3 observed differences between male and female monkeys on both learning performance and free-cage behavior parameters, and 4 a radiation-induced facilitation on difficult size discrimination problems.

Subject Categories:

  • Radiobiology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE