HYPOTHALAMIC SECRETORY FACTOR FOR ADRENOCORTICOTROPIC HORMONE (SF-ACTH).
Final technical rept. for 15 Aug 63-14 Aug 64,
HARVARD COLL CAMBRIDGE MASS PRESIDENT AND FELLOWS
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The purpose of this research is to purify the hypothalamic hormone responsible for the increased biosynthesis and secretion of ACTH in stress. This hormone, originally named corticotropin releasing factor CRF by Dr. Murray Saffran of McGill University, is now referred to as hypothalamic secretory factor for ACTH HSF-ACTH. Because the only feasible guide to yield and specific activity of HSF-ACTH is a rather complicated biological assay system, the studies have included ways to improve and simplify the biological assay for the hypothalamic secretory factor for ACTH are based on a discovery that in the rat anesthetized with pentobarbital, morphine inhibits ACTH secretion to nonspecific stimuli without intererfering with the action of HSF-ACTH on the anterior pituitary gland.