Accession Number:

AD0610569

Title:

Fate of UDMH and MMH in Rats

Descriptive Note:

Technical Report,01 Jun 1963,30 Jun 1964

Corporate Author:

OREGON STATE UNIV CORVALLIS CORVALLIS

Personal Author(s):

• Dost,F. N.
• Reed,D. J.
• Wang,C. H.

Report Date:

1964-12-01

Pagination or Media Count:

34.0

Abstract:

Many of the applications of hydrazines, especially as rocket propellants and in medicine, give them considerable toxicological importance. The respiratory and urinary excretion by rats of unsymmetrical dimethylhydrazine UDMH and monomethylhydrazine MMH and their metabolites has been studied by means of radiotracer techniques. At a very low dose, almost 30 of the C14 from i.p. administered UDMH-C14 appeared as respiratory C14O2 in 10 hours. At a convulsive dose, the conversion of UDMH-C14 to C14O2 amounted to slightly greater than 13 at the end of 20 hours. At all doses studied radioactivity appeared in the urine to the extent of at least 50 of the administered UDMH-C14, at the end of two days after administration. Rats administered MMH-C14 by i. p. injection at 20 of a median lethal dose respired approximately 45 of the administered radioactivity in 24 hours. The respired radioactivity consisted of at least two components 20-25 was C14O2, and the remainder was a C14 labeled volatile compound tentatively identified as methane-C14. At the sub-convulsive doses, 40 of the administered radioactivity in MMH-C14 was excreted in urine. At a toxic dose the percentage of urinary excretion of C14 decreased, but net molar excretion increased slightly. The design of an animal radiorespirometric system capable of continuously monitoring C14 in respiratory gases from separate animals is described.

Descriptors:

• DIMETHYLHYDRAZINES
• TRACER STUDIES
• METABOLISM
• DIMETHYLHYDRAZINES
• TOXICITY
• PHARMACOLOGY
• RATS
• EXCRETION
• RESPIRATION
• URINE
• LABELED SUBSTANCES
• RADIATION DOSAGE
• LETHAL DOSAGE
• HAZARDS

Subject Categories:

Distribution Statement:

APPROVED FOR PUBLIC RELEASE