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EFFECT OF DIFFERENT ROUTES OF CHALLENGE OF COXSACKIE B VIRUS ON COLD-STRESSED MICE,
UTAH UNIV SALT LAKE CITY COLL OF MEDICINE
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Adult albino mice were given Coxsackie B virus via intrathoracic, intraperitoneal, intranasal and aerosol routes. The mice were either acclimatized or unacclimatized to 2C ambient temperature, and in one challenged group normal mice were compared to specifically immunized animals. No deaths occurred in the control animals 21C challenged intranasally or by aerosol however, 510 mice were killed by the intrathoracic challenge and 110 died from the intraperitoneal challenge. In general the mice unacclimatized to 2C had higher mortality ratios than acclimatized animals in all challenged groups regardless of the route of challenge. Intranasally and intraperitoneally challenged mice had similar mortality ratios in all groups tested. Many of the deaths of the intrathoracically challenged mice are attributed to the procedure of challenge. The few deaths in the aerosol challenged groups are thought to be a dose-related factor. Author
APPROVED FOR PUBLIC RELEASE