BEHAVIORAL AND NEUROPHYSIOLOGICAL STUDIES OF UDMH IN THE CAT
Final rept. May 1962-Jul 1964
CALIFORNIA UNIV LOS ANGELES BRAIN RESEARCH INST
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Studies concerning the behavioral and neurophysiological actions of UDMH in cats were carried out employing three separate experimental approaches a Collection of behavioral and electrophysiological data from animals prepared with indwelling recording electrodes and isolated in a controlled environment after various doses of UDMH, b Determination of thresholds for seizure induction by electrical stimulation of the hippocampus in unanesthetized, but immobilized acute preparations, and c Development of a unique behavioral apparatus which provides for the evaluation of subconvulsive doses of UDMH in relation to specific CNS regulatory mechanisms. The latter experiment has not yet reached the stage of UDMH administration and testing. The first set of experiments disclosed a direct relationship between dose and time of onset of characteristic behavioral and EEG signs preceding convulsions. The acute experiments indicate an initial increase in ventral hippocampal seizure threshold after administration of low doses of UDMH. This change is seen for the first two hours post-injection and may be related to the initial lethargy and delay in seizure occurrence characteristic of UDMH exposure.
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