THE EFFECT OF DECABORANE INJECTION ON MACACA MULATTA AND MACACA IRUS OPERANT BEHAVIOR
Final rept. for 10 Feb-24 Feb 1964
AIR FORCE AEROSPACE MEDICAL RESEARCH LAB WRIGHT-PATTERSON AFB OH
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Ten adult monkeys, eight on negatively reinforced low level shock tasks and two on positively reinforced food reward tasks, were injected with either 2 mg, 4 mg, or 1 mg followed by 2 mg decaborane per kg body weight, and their performance on various operant tasks was compared with baseline performance. All animals exhibited a performance decrement on at least one task, with 75 of the subjects exhibiting a decrement on the remaining tasks. In over half the cases performance changes preceded clinical symptoms. There was no significant difference between the 2 mg and 4 mg exposures when a subject showed a decrement on negatively reinforced tasks. However, those subjects that received 1 mg followed the next day by 2 mg positively reinforced animals did not noticeably improve or return to baseline for a much longer period than the 2 mg and 4 mg groups negatively reinforced.