Accession Number:

AD0607532

Title:

THE EFFECT OF DECABORANE INJECTION ON MACACA MULATTA AND MACACA IRUS OPERANT BEHAVIOR

Descriptive Note:

Final rept. for 10 Feb-24 Feb 1964

Corporate Author:

AIR FORCE AEROSPACE MEDICAL RESEARCH LAB WRIGHT-PATTERSON AFB OH

Personal Author(s):

• Reynolds, Herbert H.
• Brunson, Henry W.
• Back, Kenneth C.
• Thomas, Anthony A.

Report Date:

1964-08-01

Pagination or Media Count:

44.0

Abstract:

Ten adult monkeys, eight on negatively reinforced low level shock tasks and two on positively reinforced food reward tasks, were injected with either 2 mg, 4 mg, or 1 mg followed by 2 mg decaborane per kg body weight, and their performance on various operant tasks was compared with baseline performance. All animals exhibited a performance decrement on at least one task, with 75 of the subjects exhibiting a decrement on the remaining tasks. In over half the cases performance changes preceded clinical symptoms. There was no significant difference between the 2 mg and 4 mg exposures when a subject showed a decrement on negatively reinforced tasks. However, those subjects that received 1 mg followed the next day by 2 mg positively reinforced animals did not noticeably improve or return to baseline for a much longer period than the 2 mg and 4 mg groups negatively reinforced.

Descriptors:

• *DECABORANES
• *MONKEYS
• HAZARDS
• BEHAVIOR
• PSYCHOPHYSIOLOGY
• INJECTIONS(MEDICINE)
• LEARNING
• PHARMACOLOGY
• TOXICOLOGY

Subject Categories:

• Pharmacology

Distribution Statement:

APPROVED FOR PUBLIC RELEASE